منابع مشابه
Regulation of Glomerular Endothelial Cell Proteoglycans by Glucose
The presence of heparan sulfate proteoglycan (HSPG) in anionic sites in the lamina rara interna of glomerular basement membrane suggests that the proteoglycan may be deposited by the glomerular endothelial cells (GEndo). We have previously demonstrated that bovine GEndo in vitro synthesize perlecan, a species of glomerular basement membrane HSPG. In this study we examined whether high glucose m...
متن کاملHypoxic regulation of secreted proteoglycans in macrophages.
Macrophages are prominent in hypoxic areas of atherosclerotic lesions, and their secreted proteoglycans (PG), such as versican, can modulate the retention of lipoproteins and the activity of enzymes, cytokines, and growth factors involved in atherogenesis. In this study, we report the effects of hypoxia on PG secreted by human monocyte-derived macrophages (HMDM) and the potential regulation by ...
متن کاملBiosynthesis and regulation of expression of proteoglycans.
Proteoglycans are a family of complex macromolecules characterized by the presence of one or more glycosaminoglycan chains covalently linked to a polypeptide backbone. Although originally named and categorized on the basis of the glycosaminoglycan substituent, increasingly they are being identified as members of gene families that encode their different core proteins. Proteoglycans are found pr...
متن کاملHeparan Sulfate Proteoglycans during Terminal Skeletal Muscle Cell Differentiation: Possible Functions and Regulation of their Expression
Heparan sulfate proteoglycans are key molecules found associated with the cell surface and extracellular matrix (ECM). These macromolecules seem to be essential to achieve terminal skeletal muscle differentiation. In this review, we present data about the types of beparan suifate proteoglycans present in skeletal muscle cells, how their expression changes during differentiation and we propose s...
متن کاملRegulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates.
We have demonstrated previously that chick embryo fibroblasts synthesize and secrete a large chondroitin sulfate proteoglycan (designated PG-M) that binds to fibronectin. We now report the possibility that PG-M interactions with cell surfaces can modulate cell-substrate adhesion. When PG-M was added to the medium, various types of trypsinized cells failed to adhere not only to fibronectin-coate...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)80001-1